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PRESS RELEASE
November 4, 2005

Arrowhead and Duke University Begin Work on Nanotubes to Replace Copper, the Semiconductor Industry's Weakest Link

Arrowhead Research Corp. (Nasdaq:ARWR), a diversified nanotechnology company, announced today that it will work with Duke University and Dr. Jie Liu, a leading nanotube expert, to develop nanotube-based interconnects as a replacement for copper in computer chips. Arrowhead has agreed to provide approximately $680,000 in funding over the next two years to develop Dr. Liu's technology. In exchange, Arrowhead will have the exclusive right to license the resulting intellectual property and commercialize the process developed at Duke.

"There is a burning need in the semiconductor industry for a new material to replace copper interconnects. We believe the Duke team has a unique solution to this problem," said R. Bruce Stewart, Arrowhead's president. "Our intention is to fund development of a CMOS compatible process at Duke over the next two years, and then partner with device manufacturers to integrate carbon nanotube-based interconnects into their manufacturing processes."

As consumer demand grows for smaller and faster chips, copper interconnects become more difficult and costly to fabricate. Also, copper's structural and electrical properties intrinsically degrade at smaller scales. The International Technology Roadmap for Semiconductors identifies the interconnect problem as one of the major roadblocks standing in the way of future chip fabrication.

A phenomenon known as electromigration threatens the reliability of nanometer-size copper interconnects. Electromigration causes internal and external cavities that lead to wire failure. Copper burns out at one million amps per square centimeter while nanotubes can carry up to a billion amps per square centimeter. Bundles of densely packed nanotubes can also have substantially lower resistance than copper. Although several players in the semiconductor industry have identified nanotubes as a prime candidate to replace copper, substantial challenges remain in synthesizing the materials and integrating them into chips.

"To our knowledge, corporate research groups have encountered recurring problems in the manufacturing strategies they have pursued," said Mr. Stewart. "We believe Dr. Liu and his research team at Duke have a completely different approach that could enable large volume manufacturing of nanotube interconnects in future chips."

This investment is the latest in a series that furthers Arrowhead's business model of funding university nanotech research and guiding it to the marketplace.

About Arrowhead Research Corporation

Arrowhead Research Corporation (www.arrowheadresearch.com) is a publicly-traded nanotechnology company commercializing new technologies in the areas of life sciences, electronics, and energy. Arrowhead is building value for shareholders through the progress of majority owned subsidiaries founded on nanotechnologies originally developed at universities. The company works closely with universities to source early stage deals and to generate rights to intellectual property covering promising new nanotechnologies. Currently, Arrowhead has four subsidiaries commercializing nanotech products and applications, including anti-cancer drugs, RNAi therapeutics, carbon-based electronics and compound semiconductor materials.

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995:

This news release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations and speak only as of the date hereof. Our actual results may differ materially and adversely from those expressed in any forward-looking statements as a result of various factors and uncertainties, including the recent economic slowdown affecting technology companies, the future success of our scientific studies, our ability to successfully develop products, rapid technological change in our markets, changes in demand for our future products, legislative, regulatory and competitive developments and general economic conditions. Our Annual Report on Form 10-K and 10-K/A, recent and forthcoming Quarterly Reports on Form 10-Q and 10-Q/A, recent Current Reports on Forms 8-K and 8-K/A, our Registration Statement on Form S-3, and other SEC filings discuss some of the important risk factors that may affect our business, results of operations and financial condition. We undertake no obligation to revise or update publicly any forward-looking statements for any reason.

Contacts

Virginia Dadey; Vice President, Investor Relations
Telephone: 212.541.3707
Email: vdadey@arrowres.com