Arrowhead Publications

RNAi Delivery + ARC-520

February, 2013

Christine I Wooddell, David B Rozema, Markus Hossbach, Matthias John, Holly L Hamilton, Qili Chu, Julia O Hegge, Jason J Klein, Darren H Wakefield, Claudia E Oropeza, Jochen Deckert, Ingo Roehl, Kerstin Jahn-Hofmann, Philipp Hadwiger, Hans-Peter Vornlocher, Alan McLachlan and David L Lewis, "Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection." Molecular Therapy. advance online publication 26 February 2013; doi: 10.1038/mt.2013.31.

September, 2012

Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein, Kerstin Jahn-Hofmann, Frieder Bauss, Weijun Cheng, Rebecca Croasdale, Karin Daub, Simone Dill, Eike Hoffmann, Wilma Lau, Helmut Burtscher, James L Ludtke, Silke Metz, Olaf Mundigl, Zane C Neal, Werner Scheuer, Jan Stracke, Hans Herweijerand Ulrjch Brinkmann, "Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies." Molecular Therapy Nucleic Acids (2012) 1, e46; doi:10.1038/mtna.2012.39, Published online 18 September 2012.

January, 2012

So C. Wong, Jason J. Klein, Holly L. Hamilton, Qili Chu, Christina L. Frey, Vladimir S. Trubetskoy, Julia Hegge, Darren Wakefield, David B. Rozema, and David L. Lewis, "Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs In Vivo."  Nucleic Acid Therapeutics. December 2012, 22(6): 380-390. doi:10.1089/nat.2012.0389.   

January, 2007

Rozema DB, Lewis DL, Wakefield DH, Wong SC, Klein JJ, Roesch PL, Bertin SL, Reppen TW, Chu Q, Blokhin AV, Hagstrom JE, Wolff JA (2007). “Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.” Proceedings of the National Academy of Sciences 104(32): 12982-87.